Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

*An attractive drug target among coronaviruses is the main protease (Mpro, 3CLpro), due to its essential role in processing the polyproteins that are translated from the viral RNA."

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Linlin Zhang1,2, Daizong Lin1,3, Xinyuanyuan Sun1,2, Ute Curth4, Christian Drosten5, Lucie Sauerhering6,7, Stephan Becker6,7, Katharina Rox8,9, Rolf Hilgenfeld1,2,*

1 Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, 23562 Lübeck, Germany. 2 German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Site, University of Lübeck, 23562 Lübeck, Germany. 3 Changchun Discovery Sciences Ltd., 789 Shunda Road, Changchun, Jilin 130012, China. 4 Institute for Biophysical Chemistry, Hannover Medical School, 30625 Hannover, Germany. 5 Institute of Virology, Charité Universitätsmedizin Berlin, 10117 Berlin, Germany. 6 Institute of Virology, University of Marburg, 35043 Marburg, Germany. 7 German Center for Infection Research (DZIF), Marburg-Gießen-Langen Site, University of Marburg, 35043 Marburg, Germany. 8 Department of Chemical Biology, Helmholtz Center for Infection Research (HZI), Inhoffenstraße 7, 38124 Braunschweig, Germany. 9 German Center for Infection Research (DZIF), Hannover-Braunschweig Site, Helmholtz Center for Infection Research, 38124 Braunschweig, Germany.

Science doi:10.1126/science.abb3405, 20 March 2020.

https://science.sciencemag.org/content/early/2020/03/20/science.abb3405.full