Essential proteins of Pseudomonas aeruginosa

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Short Description:

Identified novel antibiotic targets against Pseudomonas aeruginosa.

Long Description:

We propose to apply Proteome Antibiotics platform into an important human pathogen Pseudomonas aeruginosa and uncover new antibiotic targets of the organism. Pseudomonas infections, like many other hospital bacterial infections, are becoming more difficult to treat because of increasing antibiotic resistance. Multidrug-resistant Pseudomonas was given a threat level of serious threat in the CDC AR Threat report. The proposal will focus on the identification of new antibiotic targets in Pseudomonas aeruginosa. The identified antibiotic targets will support further development of novel antibiotics against Pseudomonas aeruginosa.

The growing antibiotic resistance poses a global health threat by reducing the efficacy of the current antibiotics and our ability to treat and prevent disease. The problem is urgent and demands immediate action. To combat antibiotic resistance, we developed Proteome Antibiotics as a platform approach for the identification of novel potential antibiotic targets. The platform is based on the interference with bacterial essential functions via the intracellular expression of anti-bacterial proteome nanobody repertoire, and has been validated in E. coli. Here, we propose to apply this platform into an important human pathogen Pseudomonas aeruginosa and uncover new antibiotic targets of the organism. Pseudomonas infections, like many other hospital bacterial infections, are becoming more difficult to treat because of increasing antibiotic resistance. Multidrug-resistant Pseudomonas was given a threat level of serious threat in the CDC AR Threat report. The proposal will focus on the identification of new antibiotic targets in P. aeruginosa. The identified antibiotic targets will support further development of novel antibiotics against P. aeruginosa. More importantly, we plan to make the Proteome Antibiotics platform open available for the global antibiotics research community via our open therapeutics web. Any capable and responsible researcher could use this platform for the discovery of novel antibiotics against other bacterial pathogens, reducing the cost and timeline for new antibiotic development. The success of Proteome Antibiotics platform could potentially contribute to the war against antibiotics resistance.


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